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среда, 30 сентября 2015 г.

Does Aging Increase Fertility in PCOS?

First, women with PCOS may begin life with more eggs than women without PCOS
In fact, “An important biopsy-study showed a much increased density of follicles at primary stages in polycystic ovaries compared with normal ovaries, suggesting that women with polycystic ovaries may actually be endowed with a larger ovarian reserve at birth[ii]” That means that as we age, we have more eggs left over than women without PCOS.  This increased ovarian reserve, together with other factors (discussed below) mean older women with PCOS have a better chance of pregnancy than their age matching non-PCOS counterparts[iii].
Second, ovarian aging naturally results in follicle loss.  This bodes well for women with PCOS since the major cause of infertility in women with the syndrome is that they have greater numbers of follicles or cysts on their ovaries than healthy women. As a result, they ovulate less frequently because these extra follicles interfere with their hormonal activity and prevent just a few healthy follicles from maturing. When aging naturally reduces the number of follicles, the hormonal problems should lessen (if not disappear).  This may explain the normalized menstruation cycles reported by some older women with PCOS[iv],[v] .
In addition, the study concludes that, “Thus, in women with PCOS, this age-dependent reduction in the pool of resting follicles may eventually lead to more cycles becoming ovulatory and a catch-up of fecundity.”
http://pcosdiva.com/2015/09/aging-pcos-fertility/?inf_contact_key=027cc0671bd3c273d4ef7eeaf36f1f2c9a22b804d96d0ba7a40787647dc65fec

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