Estrogen promotes breast development in women, so of course there is a strong
relationship with breast disease and the hormone that regulates breast growth – but it’s all about balance. Persistently high levels of estrogen can promote growth of abnormal cells that might otherwise have been plucked out by the immune system. This does not mean that estrogen is CAUSING cancer. But it can create an environment (which is reversible) that facilitates growth of abnormal cells if they are there.
That’s one of the reasons why having a good balance of estrogen to progesterone is so important. Progesterone has a protective effect in the setting of estrogen dominance. It counteracts the “grow, grow, grow” properties of estrogen. Women in perimenopause don’t make much progesterone because they don’t ovulate regularly, so levels are usually very low. The good news is that progesterone can be supplemented, thus helping to balance estrogen. Unfortunately, the medical community tends to lump PROGESTERONE into the category with PROGESTINS (the bad actor in the WHI Study) and this has created the fear that progesterone causes cancer.
http://www.drannagarrett.com/2015/10/the-truth-about-estrogen-and-breast-cancer-risk/?inf_contact_key=1826acd0d6ecd12b339562caae36ceaa5ddbbe0e85e6b895e4cd4f272a033d64

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